Cisplatin pharmacokinetic
WebSelect search scope, currently: articles+ all catalog, articles, website, & more in one search; catalog books, media & more in the Stanford Libraries' collections; articles+ journal articles & other e-resources WebAug 20, 2024 · Pharmacokinetic data were generated to support clinical dosing decisions, with the aim of adequate exposure and minimal toxicity. In the first chemotherapy cycle, 25% of the standard cisplatin dose and 75% of the carboplatin dose, calculated using the pediatric Calvert formula, were administered.
Cisplatin pharmacokinetic
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WebSep 15, 2024 · DESCRIPTION. Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL … WebFeb 28, 2024 · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In …
WebJun 19, 2024 · Cisplatin concentrations were determined in plasma and ultrafiltrate samples collected on each of six cycles of a monotherapy regimen, beginning with a dose of 1.6 mg/kg at 16 days of age. Pharmacokinetic data were analyzed to generate clearance (CL) and area under the curve (AUC 0–∞) for each administration. WebNational Center for Biotechnology Information
WebJan 13, 2011 · Cisplatin is one of the most effective chemotherapeutic agents against many forms of cancer including testicular, bladder, head and neck, ovarian, breast, lung, prostate, and refractory non-Hodgkin’s lymphomas ( 2, 3 ).
WebApr 5, 2024 · Pharmacokinetics. Distribution. Cisplatin dose not undergo the instantaneously and reversible binding to plasma protein that is characteristic of …
WebMar 2, 2005 · The pharmacokinetic model distinguished between active drug and their inactive (inert) metabolites in plasma and CSF. INTRODUCTION The platinum analogues, cisplatin and carboplatin, are chemically reactive anticancer drugs that produce a cytotoxic effect through platination of DNA and the formation of cross-links. dallas stars player collapses on benchWebAug 1, 2005 · Alterations in the availability of binding proteins, fluid shifts, and acid-base changes can all influence chemotherapy pharmacokinetics. Furthermore, the pharmacodynamics of these drugs can be influenced by an increased exposure to a drug's active metabolites as well as to the agent itself. dallas stars schedule 2021 2022 printableWebSep 21, 2016 · The pharmacokinetics and pharmacodynamics of docetaxel and cisplatin were compared in elderly and non-elderly patients. Results There were no differences in pharmacokinetics of docetaxel or cisplatin between elderly versus non-elderly patients with regard to clearance and volume of distribution. birchwood caravans thirskWebDec 1, 1992 · The pharmacokinetic profile of vinorelbine is often described as a 3-compartment model characterised by a long terminal half-life that varies between 20 and 40 hours and a large apparent volume of distribution (Vd) of around 70 L/kg. 86 Pulmonary distribution of vinorelbine in patients with non-small-cell lung cancer D. Levêque, E. Quoix, birchwood care home cheshamWebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … birchwood care center mnWebJan 16, 2016 · Pharmacokinetic interactions were evaluated.Methods Plasma pazopanib and ultrafilterable cisplatin concentrations were obtained in 32 patients treated according to four levels of dose corresponding to 200, 400 or 600 mg daily dose of pazopanib and 60 or 75 mg/m2 of cisplatin. Two sequences of treatment… View on Springer ncbi.nlm.nih.gov birch wood candle holdersWebCISPLATIN Although they are members of the same chemical family, cis- platin is considered to be superior therapy for specifictumor typescomparedwithcarboplatin.Unfortunately,nephrotoxicity is the dose-limiting side effect of this very effective chemother- apeutic agent (17–19). birchwood care center ohio