Chlamydomonas hap2

Author: lvrn

August undefined, 2024

WebThe structure of Chlamydomonas HAP2 suggests that the cd loop is bipartite, with the two parts split by a small alpha helix (Fe´dry et al., 2024). Given this speciﬁc structure/function biological activity observed during the study of HAP2 in Tetrahymena, Arabidopsis, and Chlamydomonas, and the general conservation of the protein WebNational Center for Biotechnology Information

Cellular fusion: Protein X-ray insights - 2024 - Wiley Analytical …

WebOct 1, 2024 · The first atomic model of HAP2 [27], a Chlamydomonas HAP2 homotrimer, revealed an unambiguous structural homology to class II fusion proteins, with the β sheet-rich domains I, II, and III arranged in the folded-back (hairpin) conformation typical of the viral proteins in the post-fusion trimer [17]. In their prefusion form on virus particles ... crystal shop shreveport

The conserved plant sterility gene HAP2 functions …

WebFeb 23, 2024 · Studies in Chlamydomonas and Plasmodium (the pathogen causing malaria in humans) revealed that hap2 mutant gametes in both organisms were fully capable of … WebOct 3, 2024 · HAP2 is a class II gamete fusogen in many eukaryotic kingdoms. A crystal structure of Chlamydomonas HAP2 shows a trimeric fusion state. Domains D1, D2.1 … WebHAP2 localizes at the fusion site of Chlamydomonas minus gametes, yet Chlamydomonas minus and Plasmodium hap2 male gametes retain the ability, using … crystal shop shuttington

RCSB PDB - 6E18: Crystal structure of Chlamydomonas reinhardtii …

RCSB PDB - 6DBS: Fusion surface structure, function, and dynamics …

WebChlamydomonas HAP2 is a member of a broadly conserved protein family whose founding member was identified in Arabidopsis in a screen for male sterile mutants (Johnson et al., 2004). [HAP2 more recently has also been termed GCS1 (Mori et al., 2006).] Previously, using gene disruption methods, we showed that in both Chlamydomonas and the rodent WebMar 23, 2010 · HAP2/GCS1 family members mediate membrane fusion between gametes in a broad range of eukaryotes, ranging from algae and higher plants to protozoans and … crystal shops grand rapidsWebJul 19, 2024 · The cytoplasmic domain of the gamete membrane fusion protein HAP2 targets the protein to the fusion site in Chlamydomonas and regulates the fusion reaction. Development 142 , 962–971 (2015). crystal shop sidmouth

"WebFeb 28, 2024 · X-ray crystallography reveals that two closely related proteins, the HAP2 protein from the single-celled alga Chlamydomonas reinhardtii and the fusion protein from dengue virus are essential for fusion with a cell membrane and thus both sexual reproduction and viral invasion of a host cell. The proteins probably emerged very early … " - Chlamydomonas hap2

Chlamydomonas hap2

Cellular fusion: Protein X-ray insights - 2024 - Wiley Analytical …

WebHAP2 is a class II gamete fusogen in many eukaryotic kingdoms. A crystal structure of Chlamydomonas HAP2 shows a trimeric fusion state. Domains D1, D2.1 and D2.2 line the 3-fold axis; D3 and a ... WebMay 3, 2024 · HAP2 is a class II gamete fusogen in many eukaryotic kingdoms. A crystal structure of Chlamydomonas HAP2 shows a trimeric fusion state. Domains D1, D2.1 …

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WebDec 20, 2024 · Furthermore, comparisons between the HAP2 structures of Chlamydomonas, Arabidopsis, and Trypanosoma cruzi showed substantial, taxa … WebOct 3, 2024 · HAP2 is a class II gamete fusogen in many eukaryotic kingdoms. A crystal structure of Chlamydomonas HAP2 shows a trimeric fusion state. Domains D1, D2.1 and D2.2 line the 3-fold axis; D3 and a ...

WebJun 15, 2024 · The kinetics of degradation of HAP2-GCS1 and FUS1 in Chlamydomonas zygotes (mentioned above) are consistent with a process activated by fresh transcription after fusion, at least in part . Remarkably, although land plants have dramatically elaborated lifecycles compared to their green algal ancestors, this ancestral function of … WebMar 26, 2008 · HAP2. Chlamydomonas, Plasmodium] Fusion of gametes of opposite sex (or mating type) to form a zygote is the defining moment in the life of a eukaryote. In the first …

WebFeb 5, 2015 · In Chlamydomonas, HAP2 is constit utively prese nt on the cel l. surface at a specialized, apically localized membrane patch, the. mating structure (Fig. 1), the surfa ce area of which repr esents ...

WebJul 19, 2024 · During the gamete membrane fusion reaction, HAP2 undergoes a fusogenic conformational change to become an SDS-resistant trimer Gamete fusion in … Metrics - Species-specific gamete recognition initiates fusion-driving trimer ... dylan ritcheyhttp://genesdev.cshlp.org/content/22/8/1051.full crystal shops in ashevilleWebIntraflagellar transport protein 46 · Gene: IFT46 (FAP32) · Chlamydomonas reinhardtii (Chlamydomonas smithii) · 344 amino acids · Evidence at protein level · Annotation score: 5/5. ... A4GRC6 · … dylan richter new bandWebMar 1, 2015 · Early reports on HAP2 in Arabidopsis concluded that it was required for gamete attachment (Mori et al., 2006), but by exploiting the ease of experimentally identifying and quantifying the location and properties of HAP2 at individual steps in gamete fusion in the green alga Chlamydomonas and the malaria pathogen Plasmodium … dylan right recruitmentWebFeb 23, 2024 · "The HAP2 protein from Chlamydomonas is folded in an identical fashion to the viral proteins," Rey said, referring to the molecular folding that creates the three-dimensional structure of all ... dylan roberts fbWebDec 31, 2016 · Structural modeling of the HAP2/GCS1 protein family predicts that they are homologous to EFF-1 and class II fusion proteins from enveloped viruses (e.g. dengue and Zika viruses). crystal shops in asheville ncWebJan 10, 2024 · HAP2/GCS1 proteins share a similar structure with two distinct families of exoplasmic fusogens: the somatic Fusion Family (FF) proteins discovered in nematodes, … dylan rings montgomery al